辛克莱教区会解锁什么

hey， hey， andy gonna be okay well lucky for him yours truly has a bit of feel medicine training can think my old man for that go and ride with mj do my best to keep him comfortable well， y'all better haul ass only a matter of time before slimming his boys sniffed this place out， let's roll roxy shit the folder can't you grab it from the house sure thing i'll meet you back at lobos with it that rocks on stains don't boy i spent a long hour's thinking about putting a bullet in your head but then it keats when i hand you over to my friends here let them take the time with you looks like your crack ass friends decided to bust out the halloween costumes they slim didn't that tell you all this one was special your people split boy sure they might have gotten a few witnesses out of saying claire but this this was really important without it it's just gonna be the worst and goddamn nick is against the word of a god for fear and white man if that's all said and done hell i'll probably get elected governor glad to see you haven't lost your ambition you know what a problem with you people is you still think you can win that you got something to win but it ain't never gonna come to pass wants a filthy nega always a filthy nega go on have you found oh still motherfucker god damn where'd that come from oh shit don't worry about me baby i got the high ground you get slam remember we need him alive losing guys like this shit we gotta reload something to warn you up boy 来一碗！ oh！ come on！ digger！ come on got eyes on liam fuck is hitting my way he looks gay keep firing on him what is that airbo out of here put you down here oh my god！ cockroach feather the fuck up down bitch rockstar get out of there oh shit！ rockstar！ rockstar get this from here some days are done or you got some fight in you yeah fuck is trying to flip not through the field you got nine lives or something your ass should throw you lucky we saw that fire when we were driving out you ain't leading saint grandparents alive boy blambo has been coming up older ah watch the pain watch the pain you got no deputy or you got some fire in you don't you pick up fucking trash on card as ron while you have to change back here just like with donnie you're a way out of line boy it ain't like that shit is a small target drag him like this all the boy look don't let this corp hold cuts of our dragon base oh you got so fire you got company on our ass as run while you have to champ you ain't leave a sink perish alive boy you're close enough for me to take a shot got it there ain't no mo run slip come on boy i got some for you oh yeah i got some of you boy you hear you motherfucker funny i saw that down my front porch rock and chair we'll go on finish it no killing you won't accomplish anything but letting you live making you answer for the shit you've done that's where the change begins besides you gotta figure being awhile racist cops gonna make you real popular in the sailblock i know people i know powerful people i ain't going up come on i think it's about time we get the hell out of syncler parish we should get him on up back to my dad， please he gonna be happy to hear about slim slim boys are coming up older， don't protect the fucking track got company ally hey shit chicken we got more deputy oh， let them put the trash on cocks got company on i a bye bye baby let me blow the history inside shit shit go all unit searches called off repeat abandoned search return to patrol， we should get it on up back to my dad， please he gonna be happy to hear about flint hey， you will not roxy huh be a hell of a lot better when we get slambormin on the lock and keep you dare real good lincoln clay this fuck is over here watch the paint watch the paint where do you want to slim go with chicken with my dad he needed no one going on sooner or lady you're gonna have to learn how to duck oh mine still breathing his ass is out in the garage rockstar handle herself all right shit she was better than all right that girl has bad levo uh huh well you did your part so you gonna stick around we could use your help just saying you always got a place for this lincoln， it was nice seeing you again levo sooner later you go have to live your life again don't forget that come in hey and now just wanted to say you okay yeah， so actually no， i ain't okay part of me wonders if any of this don't even matter we take out that motherfucker slam and all i see is paying ugliness in the world someone once told me that if all you look for in the world is evil that's all you ever gonna see truth is roxy lavo you are one of the brightest lights i have ever know don't let the world take that away from you dance with me oh i don't i don't really did come on to me okay maybe just one so if i'm so brave then what are you i'm not sure i can answer that you sell yourself too show you do you think all you got is brew false but there'd be a light inside you two linking clay how you know that well yeah cause you're here dancing with me roxy you follow your heart i know i love you。

keeping it logged down the bow sinclair you think you deal with one thing you did a good job with slam the feds have him， but he's doing as damned as to change that， but all that evidence it's the start but more folks in sinclair need to speak up and they came if the sheriff's department and whoever else has terrorized them where can i start i can point you to some concerned citizens in claire let me see what i can do to help thank you help them and will be a step closer to keeping slim beaumont behind bars you remus question remus esquire and you're all of those acquaintance remind the mess i understand you can help me get my blanch back blanch your woman or slim one with her well you see i've had occasion to perform legal services for shelf bowmont along with them not so legal services now slim's afraid you'll talk， but he doesn't want you dead which is why his folks kidnapped my blanch see there keeping her over in a scrap yard the one that got blown up i know it save save her and i'll sing like a proverbial canary cocksup is gonna pin this on us you want to keep your voice down slims people are solid the man looked out for us we looked out for his deputy slim ain't been around be the worst part of your face army sometimes y'all bust his ass so sam peace， but so i'll catch that apple motherfucker learned his lesson can't do shit 看后视镜 how can it go that big why did that motherfucker run off too nothing okay come on let's move it's dropping us got eyes on him give me a hand i'm gonna put one food mailboy units missions interventional on foot officers investigating suspect described as cullen mail， twenty five above every sight back up i know we got how to deal with this boy suck danny just pull it in your brain who we ain't got time for who what went go out the back way， christian's waiting for you at his place get those assholes all right help me out nobody help me got eyes on the suspect suspect let's go taking govern renee move your ass and against them all to put an animal down hey， get down shit need more ammo shit i'm taking many of us lamp i'm a， i'm bleeding bad 啊啊！ figured you be in the wind by now well， there's two o'clock train ticket with our names on them fake names of course but you'll testify if it means not having to look over my shoulder for the rest of my life yeah here i'll testify you take care of her now。

破解线粒体功能障碍的白藜芦醇。下次当你举起酒杯为某人的健康干杯时，别忘了为我们的好朋友兼思想伙伴大卫新客来敬上一杯。他发现了白藜芦醇这种物质模拟了热量限制对新陈代谢的影响。为什么？这很重要？ 首先我要说明的是，新克莱可能是世界上最伟大的去乙酰化酶研究专家。去乙酰化酶是一类调节细胞功能的基因。 根据你的身体在给定时间内可获得的卡路里数量，线粒体中的去乙线化酶调节着代谢生长， 而线粒体是几乎所有细胞内产生能量的细胞器。当食物充足时，你的细胞分裂生长的更快。当热量不足时，比如你进食时，你的细 包会进入管家模式分解并重新吸收游离的蛋白质，以供再次利用。这种现象被称为自视，源于拉丁语中的自我和吞食。 虽然长寿科学领域存在很多分歧，但几乎所有专家都认为热量限制有助于保持甚至恢复青春和健康。对从果银到人类的生物进行的实验已经明确表明，限制卡路里摄入可以缓解衰老的许多特征， 从而实现延年益寿。根据精神病学家丹尼尔亚蒙 danilyman 插图的说法，限制热量摄入可以改善大脑健康。 限制热量摄入可以使身体处于良好的应激反应状态，减少贝塔减淀粉，让蛋白在大脑中的滞留时间，并启动一系列抗衰老机制。然而，建议人们让自 自己挨饿肯定不会被大多数人采纳。因此，新克莱开始寻找一种物质，它既可以帮助我们获得线粒体健康带来的与限制热量相同的益处，又不会让我们产生饥饿感。最终，新克莱从法国获得了灵感。 尽管法国人在饮食中摄入了大量饱和脂肪，但他们的冠心病发病率是世界上最低的， 这就是所谓的法国悖论。新客来推测，法国人饮食中的某种东西可能是他们的心脏保持健康的原因。这种东西就是红酒。 具体来说，他是红葡萄酒中一种叫做白藜芦醇的分子，来自生长在恶劣环境中的黑比诺和小希拉等黑葡萄。新客来从理论上推测，白藜芦醇可以帮助葡萄忍受恶劣环境并存活下来， 也可以通过激活线粒体的去乙腺化酶反应对人类起到相同的作用。新克莱在一项实验中给酵母细胞喂食白藜芦醇。结果显示，与那些未食用白藜芦醇的酵母细胞相比，建设喂食的酵母细胞多活了相当于人类五十年的时间。插图， lifespan 一百三十这项实验后来在如虫、小鼠以及最终在人类身上产生了相同的结果。这听起来似乎是一个笑话中的妙语。辛克莱博士写道，我们不仅发现了一种模拟热量限制的物质， 这种物质可以让你在感觉不到饥饿的情况下延长寿命，而且是在一瓶红酒中发现的。插图， left pan 幺三幺在你为了长寿而大量饮用葡萄酒之前，你应该了解，只有通过 摄入高浓度的白藜芦醇才有可能获得你希望达到的效果。许多人坚信，适量饮用红酒对健康有益，至于你需要喝多少红酒才能显著延长自己的寿命，可能任何人建议的量都远远不够，因此，我们对长寿分子的研究仍在继续。

好久没发彩蛋视频了，今天带大家看看荒野大雕刻二中的彩蛋。时间旅行者首先到地图的这个位置，会发现有一个陌生人任务，靠近对话就能触发任务。对话中会发现这是一位行为很怪异的男子，拜托亚瑟去找到石雕。需要注意的是，这名男子脸上有非常明显的胎记， 对话结束后就可以开始寻找石雕。石雕的位置十分隐蔽，建议大家查攻略寻找。寻找石雕的过程中，你会发现石雕上的内容仿佛不是这个世界的产物，貌似描述的是时间悖论。找其全部石雕位置后，到任意一家邮局寄出石雕坐标 本，第二天再来就能收到神秘男子的报酬。这里吐槽一下，辛辛苦苦跑了一圈地图找石雕就给十块钱，不过还可以获得一件独一无二的岩石雕像。第三天再来邮局就能收到佛朗西斯的邀请，信心中他表示不久将要去旅行，想要再见我 我们一面。于是再次来到最开始接任务的小服务，推门进去就能看到一副具有现代文明的绘画，这些正是由石雕组成的。这是一位抱着孩子的妇女进来说这位孩子就是佛朗西斯，恐怖的地方在于证明孩子和佛朗西斯的特征一模一样，麦色皮肤，红色头发，明显的胎记。看到这里亚瑟可能已经蒙了， 我玩到这里的时候也是吓了一跳。种种迹象表明，先前遇到的弗朗西斯就是来自未来，穿越回来寻找时间的秘密。那么问题来了，未来的弗朗西斯好不容易回来，为什么不见自己母亲一面？信中表示要去旅行，又是要去到哪个时间节点？为什么没等到亚瑟就匆忙离开？ 难道是从石雕中发现了什么秘密？细思极恐！有见解的小伙伴欢迎评论区留言。好了，我是小吴，咱们下期再见！

so for many decades scientists have known that as we get older， we lose our capacity to repair dna and this leads to cancer and overall aging and deterioration in this new study we've discovered what we think is a main mechanism that controls this process and even we think some ways to reverse it what we've discovered？ specifically is that when we're young， there's a protein that repairs our dna efficiently but as we get older， there's another protein that sticks to it and that stops it from working in one experiment we fed old mice the equivalent of about an eighty year old human a molecule called na men which then the mice turned into another molecule called nad now nad is essential for life and what we found out is that when you add it to the mouse's diet it pops， these two proteins apart and this protein can now be as active as it was in a young mouse and restore our youthful levels of dna repair effectively this restored the dna capacity of the old mice back to that of a young mouse and also removed the dna damage that was accumulating in their tissues in another experiment， we exposed the mice to radiation and our treatment greatly improved their dna repair capacity and lessen the effects of the radiation exposure we're particularly excited about doing human，

这个人，你绝对不希望他失败，大卫新客来他的研究，他说的话，喝冷娜，秦始皇听了都想爬出来了。遗传学家，哈佛大学医学研究中心主任，时代杂志最具影响力一百人说，衰老是一种病，既然是病，那就可以治喽。那这病治好了，那不是 对的。有两套信息系统编码，我们人体人类基因组 dna 这个我们熟悉，还有一套表观基因组，其实是的，这个很关键啊， dna 确实是老大，他发指令造不同功能的蛋白质，这个 东西爸妈给的，每个细胞都一样，认了。但是我们人体呢？万一的细胞，不同部位，肌肉、骨骼、大脑、眼睛等等拥有很多不同功能的细胞，谁决定了呢？表观清楚 dna 的秘书， dna 发命率，他可以选择发多少，怎么发，啥时候发，还可以修饰。所以啊， 不要把秘书不当回事很重要。表观金主开关，修饰控制 dna 的不同部分，他告诉细胞，你要成为什么类型的细胞，从而实现了特定的功能。 比如说，我们眼睛中的特化细胞，选择开启了一段的命令，产生可以探测光线的蛋白质，于是我们眼睛可以看见，显然跟我们皮肤上的普通细胞他不一样。 此时我们最讨厌的问题就来了，看这两张，点左边，现在右边，用过千百次的，用了太久了，自然就伤痕累累。他上面的数据还在吗？在啊，就是没那么容易读取了。这就是我们人体的尴尬。对于左边的是年轻时候的细胞，右边的细胞伤痕累累，他老了，啥意思呢？就是 dna， 他还是 dna 变小。我们人体的底层代码一直没有变，但是随着我们人体每分每秒无数细胞脂肪同时无数细胞补上的这一循环，读取 dni 信息 的能力越来越弱了，脑细胞有一天分裂，嘎吱一下，哎，不牛逼了，成了普通的皮肤细胞了，不再控盘了，控盘能力越来越弱了，越来越多的功能细胞走向平衡， 脑细胞越来越像皮肤细胞，表现为记忆的衰退和思考力的下降。上面我们说的眼睛中能产生探测光线的蛋白质的那种，特别的是神经细胞也同样的趋势，走向了皮肤细胞于是老了，视力下降，退化，其他的各种功能细胞也一样，变得平庸，人就真的就老了。本来就应该是这样的， 如果没有表观精准， dna 都一样，每个细胞他不就应该是一样吗？那我们人体就没有这么复杂了。要想长寿，确实就应该是这个方向，细胞越单一，寿命越长，瞎表达个啥，比如灯塔水母多纯，人家永生。注意，这里有个大家熟悉的，近几年常被说的衰老的原因之一，就是每次细胞分裂， 蓝色体上的端粒一次一次的变短，所以人体衰老等等。还有其他的几种说法，这些都是表观基因组这套人体信息系统造成的基因表达信息丢失造成的果 是衰老的特征，不是因。既然找到了因，那衰老这个过程可以被量化吗？可以啊，史蒂芬霍瓦特，加州大学人类遗传学与生物统计学教授开发了霍瓦特衰老时钟，一种高度精确的衰老分子生物标志物，能准确的读取你的生物学年龄，就是不要看你才三十，头都快秃了。一侧五十， 把它看成是细胞老化的刻度就行，所以顺其自然的也就能精确的计算出你什么时候死。当然，中途自己作的，那不算衰老。既然能这么被量化了，那这一个过程可以减速吗？甚至从此叽叽歪歪的这么久，这才是我们关心的。此时的科学家们眼睛就 习惯性的看向了笼子里面瑟瑟发抖的老鼠，那就试试吧，既然衰老是由于 dna 表达信息丢失造成的，那加速丢失是不是就老的更快了呢？这对双胞胎老鼠看价值，兄弟，咱们同年同日同月生的，你咋毛发都白花了呢？不仅如此，仔细一测，体内各种器官全部衰老，老的差不多百分之五十， 那现在是不是证明了他的这套理论是对的？此时是不是特别无聊，要加速干啥？及时的赶紧上怎么减缓吧，要减缓那就要找方法维护，保养好表观精准，你慢点蹦咋弄？就 问那些长寿的生物，他们的策略就是真的就是长保养，不在生存模式的时候就开始保养，产生一种酶来修复表观精度，保持基因信息的持续表观表达，用这些霉去老鼠身上以事业。同样又是双胞胎兄弟，各种比各种侧年轻 好多啊，至于是什么梅呢？上一次内球笑这些紧急期刊有很多的研究论文，具体名字我就不提了，被玩保健的那些人给玩坏了，不舞蹈大家了，大家指导下。通过化学物质可以严甩衰老增益技术以 已经走了很远了，不要一停到在家就切，而有很多人，他正在享用这些技术，而且可以肯定的是，有一部分人已经走到了人类不老的前沿，正在享受我们认为科幻。看看几个月前新客来教授参加 lex 飞了买访谈，社会样子，看得出这老人家五十二岁了吗？ 六九年生的。再看看贝佐斯，和他的小女友很般配吧。贝佐斯在老人家已经五十七岁了，其他的就不方便举例了，贝佐斯他们也不是最顶端的。其实这些人已经早就不满足于仅仅是减缓了虫子，敢不敢想？就是上面说的光盘被擦伤了，修复个 啥，保养个啥，直接重新刻张新的不就更完美了吗？可以。贝多斯和俄罗斯亿万富豪尤里米娜一起投资了一家公司，很多人都在抢这家公司， 有你米娜尔背后是谁就不用我说了吧，看看人家那谁，那是越活越年轻，越活越猛啊，这家公司有谁呢？三中森林是他发现了上面我们说的重置技术， 把人体细胞从八十岁逆转至四十岁的生物从编程技术，并以这项生物从编程技术获得了二零一二年的诺贝尔奖。还有科学家贝尔蒙特，他成功的在老鼠身上了十 见了。这项从编程技术他有没有在人身体上实践过呢？不知道，但是这个人名声很臭，干过很多疯狂的不合能力的实验，找他肯定是有原因的。还有一位就是上面我们说的开发生物石中的霍瓦特，还有很多其他的牛人理论和老鼠实验的成功，让我们不得不问呐，我们人的 漏起可以被重置吗？那能重置多少次呢？还几次巨富贵，让我们想想都漏啊。开搞吧！哗啦啦的二点七亿美金已到账，有权的有钱的，这么好的日子， 天天想着怎么向天再借五百年呢？活不久，香车美女，豪宅，舔狗们瞬间都不香了。活得久才是真实力，才是更高维度的权利。 古往今来，要长命百岁，无非三种方式，一种我们过去几千年的糟粕，玩神弄鬼的我们统称为无数，显然是邪的，害了很多人没用。一种现代医学，打那啥，哪里不行换哪里，很残忍很闲的，很恐怖， 上有老下有小的，不说了。还有就是刚说的技术不伤害其他人的，靠纯技术实现了人类寿命增长。不同于前两种写下的，这种技术的补给 最终受益于每一个人。前期咱们就别想了，只希望他们快点跑。批发的时候我还在，下期我们一起去研究研究。几千年一直就在那里的我们的山川地理越来越看不懂了，常回基地看看，谢谢。